According to The Sun, the stress of the situation made Roxanne physically sick.
A source told the publication: 'Roxanne was visibly stressed and told producers she hadn't slept in days. She left the set and was sick immediately.'
A spokesperson for Roxanne has declined to comment to MailOnline.
The actress told Jeremy Vine, 53, on his Channel 5 show: 'I got it completely wrong,' as the 35-year-old addressed the 'punching' row for the first time following her exit.
Having asserted that Ryan, 34, had deliberately hurt her when he playfully jabbed her while in the house, she now realises she made a mistake.
Roxanne, who quit the show on Saturday, said: 'The first thing I did when I came out of the house was look back at the footage and I really got it wrong.
'At the time it hurt but when I looked back at the clip as soon as I left the house, it was the first thing I did and I got it wrong, I really got it wrong…
'I agree fully with every single person who was outraged. I shouldn't have questioned Ryan's motivation. I got that wrong.'
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